What types of genetic issues can affect IVF success?

Genetic issues that can impact IVF success include abnormal karyotypes, balanced translocations, single-gene mutations, and sex chromosome abnormalities. Couples in consanguineous marriages may carry recessive genetic disorders. Additional factors such as mitochondrial DNA mutations, genetic syndromes affecting reproductive organs, and genetic causes of very low sperm count can also reduce the chances of successful conception and implantation.