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Pre Implantation Genetic Testing Screening

Starting a family is a journey of hope. For some, this path comes with concerns about genetic conditions or recurring pregnancy challenges. Preimplantation Genetic Testing (PGT) is a state-of-the-art procedure performed during an In-Vitro Fertilisation (IVF) cycle. It involves testing embryos for specific genetic or chromosomal abnormalities before they are transferred to the uterus. This powerful tool empowers you with crucial information, helping fertility specialists select the healthiest embryo for transfer and giving you the best possible start.

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What is Preimplantation Genetic Testing (PGT)?

Think of PGT as the very first health check for your future baby. It’s a special test we can do on embryos made during your IVF cycle, before one is transferred to your womb.By testing just a few cells from an embryo, we can check its genetic health. This helps us choose the embryo that has the best chance of developing into a healthy baby and lowers the risk of a miscarriage.

For families who have a health condition that can be passed down, PGT is a powerful tool. It helps us find an embryo that does not have that specific condition. This gives you the best chance to have a healthy child and can stop the health concern from being passed to future generations of your family.

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Types of Preimplantation Genetic Testing

PGT-A (Aneuploidy Testing)

PGT-A checks whether an embryo has the correct number of chromosomes. It helps identify embryos with the normal 46 chromosomes, reducing the risk of implantation failure, miscarriage, and chromosomal conditions such as Down syndrome.

PGT-M (Monogenic Testing)

PGT-M screens embryos for specific inherited genetic disorders, such as Cystic Fibrosis, Thalassemia, Sickle Cell Anaemia, and Huntington's disease, helping reduce the risk of passing these conditions to your child.

PGT-SR (Structural Rearrangement Testing)

PGT-SR is recommended for individuals with chromosomal rearrangements, such as translocations or inversions. It identifies chromosomally balanced embryos, increasing the chances of a healthy pregnancy.

Who Should Consider PGT?

Fertility specialists may recommend PGT if you:

  • Are of advanced maternal age (typically over 35).
  • Have experienced recurrent miscarriages.
  • Have had several failed IVF cycles.
  • Are a known carrier of a single-gene disorder (for PGT-M).
  • Have a family history of a genetic condition.
  • Are a known carrier of a chromosomal structural rearrangement (for PGT-SR).
  • Wish to reduce the risk of a multiple pregnancy by confidently transferring a single, healthy embryo.
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How Does PGT Work? – Step-by-Step Procedure

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IVF Cycle

A standard IVF cycle is performed where eggs are retrieved from the female partner and fertilised with sperm in an advanced embryology laboratory to create embryos.

Benefits of Preimplantation Genetic Testing

Choosing PGT can offer significant advantages and peace of mind:

Increased Chance of Implantation

Transferring a genetically normal embryo increases the likelihood of successful implantation in the uterine wall.

Reduced Risk of Miscarriage

Since chromosomal abnormalities are a leading cause of early pregnancy loss, PGT helps reduce the risk of miscarriage.

Lower Risk of Genetic Disorders

PGT screens embryos for specific genetic conditions, significantly reducing the risk of passing inherited disorders to the child.

Confidence in Single Embryo Transfer (SET)

By identifying the healthiest embryo, PGT supports confident single embryo transfer, lowering the risks associated with multiple pregnancies.

Fewer IVF Cycles

Improving the success of each embryo transfer can reduce the number of IVF cycles needed, saving time, cost, and emotional stress.

Risks and Limitations

It’s important to understand the limitations of PGT:

  • No Guarantee: While PGT improves success rates, it does not guarantee a successful pregnancy or live birth.
  • Potential for No Transferable Embryos: In some cases, testing may reveal that none of the embryos are genetically normal. While this news can be difficult, it prevents the emotional and physical toll of transferring an embryo that would not have resulted in a healthy baby.
  • Inconclusive Results: Rarely, a result may come back as inconclusive or show “mosaicism” (a mix of normal and abnormal cells), requiring a detailed discussion with medical experts.

Preparing for PGT

The journey with PGT begins with a thorough consultation. Preparation typically involves:

Fertility Evaluation

A comprehensive evaluation will be conducted to ensure IVF is the right path for you.

Emotional Support

The process can be emotionally demanding. Support and guidance are available at every step.

We encourage you to schedule a private consultation with our team to discuss your specific situation and receive a detailed financial plan tailored to your needs.

Patient Stories

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Still have Questions?

Is PGT (Preimplantation Genetic Test) safe for embryos? plus icon

Yes, PGT is considered very safe. A few cells are taken from the embryo’s outer layer (future placenta), not the part that becomes the baby. It’s been widely used for years without affecting child health.

What is the success rate of PGT (Preimplantation Genetic Test)? plus icon

PGT increases the success rate of pregnancy by selecting chromosomally normal embryos, enhancing implantation and lowering miscarriage risk. This helps reduce the number of IVF cycles needed for a healthy pregnancy.

Are there any risks associated with PGT (Preimplantation Genetic Test)? plus icon


PGT is generally very safe. The main risk is a less than 1% chance of embryo damage during biopsy. There’s also a small chance the test may yield no results or that no normal embryos are found.

Does PGT (Preimplantation Genetic Test) guarantee a healthy baby? plus icon

PGT significantly lowers the risk of genetic conditions like Thalassemia or Down Syndrome by selecting the healthiest embryos. However, it does not guarantee a healthy baby, and regular prenatal care during pregnancy is still necessary.

What is PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)? plus icon

PGT-SR detects structural changes in chromosomes such as translocations or inversions. It identifies embryos with normal structure, reducing the risk of implantation failure, miscarriage, or genetic conditions.

What is PGT-M (Preimplantation Genetic Testing for Monogenic Disorders)? plus icon

PGT-M identifies specific gene mutations or single-gene disorders in embryos. Its recommended for couples who are carriers of inherited disorders like autosomal recessive or X-linked conditions. This testing helps select embryos free from those genetic diseases.

What is PGT-A (Preimplantation Genetic Testing for Aneuploidy)? plus icon

PGT-A screens embryos for chromosomal abnormalities like aneuploidy. It helps identify embryos with the correct number of chromosomes, improving implantation chances and reducing miscarriage risks or birth defects.

Who should get the genetic testing done? plus icon

Genetic testing is recommended for couples with a family history of genetic disorders, recurrent miscarriages, failed IVF attempts, or advanced maternal age. It helps in identifying potential genetic risks and supports personalized fertility treatment planning.

What is PGT? plus icon

Preimplantation Genetic Testing (PGT) is performed on embryos created via IVF. It involves testing a few cells from the embryo to detect genetic abnormalities, allowing fertility specialists to select the healthiest embryos for transfer, increasing pregnancy success and reducing the risk of genetic diseases.

What is genetic testing? plus icon

Genetic testing is a medical diagnostic procedure that examines a person’s genes, chromosomes, or proteins to identify any changes or mutations. It helps assess risks for genetic conditions or the likelihood of passing them to future generations, playing a vital role in reproductive medicine and fertility planning.

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